RapamycinFungusV1, Main, Exploration, bibRecord, 001751

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

Identifieur interne : 001751 ( Main/Exploration ); précédent : 001750; suivant : 001752

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

Auteurs : Yoshimi Honma [Japon] ; Aiko Kitamura ; Ryo Shioda ; Hironori Maruyama ; Kanako Ozaki ; Yoko Oda ; Thierry Mini ; Paul Jenö ; Yasushi Maki ; Kazuyoshi Yonezawa ; Ed Hurt ; Masaru Ueno ; Masahiro Uritani ; Michael N. Hall ; Takashi Ushimaru

Source :

The EMBO journal [ 0261-4189 ] ; 2006.

RBID : pubmed:16888624

Descripteurs français

KwdFr :
- ARN ribosomique (physiologie), Liaison aux protéines (MeSH), Milieux de culture (composition chimique), Noyau de la cellule (métabolisme), Nucléole (métabolisme), Protein-Serine-Threonine Kinases (MeSH), Protéines G (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de Saccharomyces cerevisiae (physiologie), Protéines nucléaires (métabolisme), Protéines ribosomiques (métabolisme), Protéines ribosomiques (physiologie), Ribosomes (physiologie), Saccharomyces cerevisiae (métabolisme), Saccharomyces cerevisiae (ultrastructure), Sirolimus (pharmacologie), Transport biologique actif (MeSH).
MESH :
- composition chimique : Milieux de culture.
- métabolisme : Noyau de la cellule, Nucléole, Protéines G, Protéines de Saccharomyces cerevisiae, Protéines nucléaires, Protéines ribosomiques, Saccharomyces cerevisiae.
- pharmacologie : Sirolimus.
- physiologie : ARN ribosomique, Protéines de Saccharomyces cerevisiae, Protéines ribosomiques, Ribosomes.
- ultrastructure : Liaison aux protéines, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Transport biologique actif.

English descriptors

KwdEn :
- Biological Transport, Active (MeSH), Cell Nucleolus (metabolism), Cell Nucleus (metabolism), Culture Media (chemistry), GTP-Binding Proteins (metabolism), Nuclear Proteins (metabolism), Protein Binding (MeSH), Protein-Serine-Threonine Kinases (MeSH), RNA, Ribosomal (physiology), Ribosomal Proteins (metabolism), Ribosomal Proteins (physiology), Ribosomes (physiology), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae (ultrastructure), Saccharomyces cerevisiae Proteins (metabolism), Saccharomyces cerevisiae Proteins (physiology), Sirolimus (pharmacology).
MESH :
- chemical , chemistry : Culture Media.
- metabolism : Cell Nucleolus, Cell Nucleus, GTP-Binding Proteins, Nuclear Proteins, Ribosomal Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Sirolimus.
- chemical , physiology : RNA, Ribosomal, Ribosomal Proteins, Ribosomes, Saccharomyces cerevisiae Proteins.
- ultrastructure : Saccharomyces cerevisiae.
- Biological Transport, Active, Protein Binding, Protein-Serine-Threonine Kinases.

Abstract

The protein kinase TOR (target of rapamycin) controls several steps of ribosome biogenesis, including gene expression of rRNA and ribosomal proteins, and processing of the 35S rRNA precursor, in the budding yeast Saccharomyces cerevisiae. Here we show that TOR also regulates late stages of ribosome maturation in the nucleoplasm via the nuclear GTP-binding protein Nog1. Nog1 formed a complex that included 60S ribosomal proteins and pre-ribosomal proteins Nop7 and Rlp24. The Nog1 complex shuttled between the nucleolus and the nucleoplasm for ribosome biogenesis, but it was tethered to the nucleolus by both nutrient depletion and TOR inactivation, causing cessation of the late stages of ribosome biogenesis. Furthermore, after this, Nog1 and Nop7 proteins were lost, leading to complete cessation of ribosome maturation. Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes.

DOI: 10.1038/sj.emboj.7601262
PubMed: 16888624
PubMed Central: PMC1553199

Affiliations:

Japon

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001774
to stream Main, to step Curation: 001774

Le document en format XML

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<front><div type="abstract" xml:lang="en">The protein kinase TOR (target of rapamycin) controls several steps of ribosome biogenesis, including gene expression of rRNA and ribosomal proteins, and processing of the 35S rRNA precursor, in the budding yeast Saccharomyces cerevisiae. Here we show that TOR also regulates late stages of ribosome maturation in the nucleoplasm via the nuclear GTP-binding protein Nog1. Nog1 formed a complex that included 60S ribosomal proteins and pre-ribosomal proteins Nop7 and Rlp24. The Nog1 complex shuttled between the nucleolus and the nucleoplasm for ribosome biogenesis, but it was tethered to the nucleolus by both nutrient depletion and TOR inactivation, causing cessation of the late stages of ribosome biogenesis. Furthermore, after this, Nog1 and Nop7 proteins were lost, leading to complete cessation of ribosome maturation. Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes.</div>
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<Abstract><AbstractText>The protein kinase TOR (target of rapamycin) controls several steps of ribosome biogenesis, including gene expression of rRNA and ribosomal proteins, and processing of the 35S rRNA precursor, in the budding yeast Saccharomyces cerevisiae. Here we show that TOR also regulates late stages of ribosome maturation in the nucleoplasm via the nuclear GTP-binding protein Nog1. Nog1 formed a complex that included 60S ribosomal proteins and pre-ribosomal proteins Nop7 and Rlp24. The Nog1 complex shuttled between the nucleolus and the nucleoplasm for ribosome biogenesis, but it was tethered to the nucleolus by both nutrient depletion and TOR inactivation, causing cessation of the late stages of ribosome biogenesis. Furthermore, after this, Nog1 and Nop7 proteins were lost, leading to complete cessation of ribosome maturation. Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

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